Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains.
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes.To gain insight into the structure and function of bivalent domains, we mapped key histone modifications and subunits of Po